Shared features in the pathobiology of babesiosis and malaria

Peter J. Krause, Johanna Daily, Sam R. Telford, Edouard Vannier, Paul Lantos, Andrew Spielman

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations


The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalTrends in Parasitology
Issue number12
StatePublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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