Shared features in the pathobiology of babesiosis and malaria

Peter J. Krause; Johanna Daily; Sam R. Telford; Edouard Vannier; Paul Lantos; Andrew Spielman

doi:10.1016/j.pt.2007.09.005

Shared features in the pathobiology of babesiosis and malaria

Peter J. Krause, Johanna Daily, Sam R. Telford, Edouard Vannier, Paul Lantos, Andrew Spielman

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.

Original language	English (US)
Pages (from-to)	605-610
Number of pages	6
Journal	Trends in Parasitology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2007.09.005
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2007.09.005

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title = "Shared features in the pathobiology of babesiosis and malaria",

abstract = "The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.",

author = "Krause, {Peter J.} and Johanna Daily and Telford, {Sam R.} and Edouard Vannier and Paul Lantos and Andrew Spielman",

note = "Funding Information: We dedicate this review to the memory of Dr. Andrew Spielman who died shortly before its completion. Beloved teacher, mentor and friend; he is sorely missed. This study was supported by Grant M01 RR06192 (P.J.K.) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. ",

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language = "English (US)",

volume = "23",

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journal = "Trends in Parasitology",

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AU - Daily, Johanna

AU - Telford, Sam R.

AU - Vannier, Edouard

AU - Lantos, Paul

AU - Spielman, Andrew

N1 - Funding Information: We dedicate this review to the memory of Dr. Andrew Spielman who died shortly before its completion. Beloved teacher, mentor and friend; he is sorely missed. This study was supported by Grant M01 RR06192 (P.J.K.) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.

PY - 2007/12

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N2 - The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.

AB - The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.

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Shared features in the pathobiology of babesiosis and malaria

Abstract

ASJC Scopus subject areas

UN SDGs

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