TY - JOUR
T1 - Severe influenza in 33 US hospitals, 2013–2014
T2 - Complications and risk factors for death in 507 patients
AU - Shah, Nirav S.
AU - Greenberg, Jared A.
AU - McNulty, Moira C.
AU - Gregg, Kevin S.
AU - Riddell, James
AU - Mangino, Julie E.
AU - Weber, Devin M.
AU - Hebert, Courtney L.
AU - Marzec, Natalie S.
AU - Barron, Michelle A.
AU - Chaparro-Rojas, Fredy
AU - Restrepo, Alejandro
AU - Hemmige, Vagish
AU - Prasidthrathsint, Kunatum
AU - Cobb, Sandra
AU - Herwaldt, Loreen
AU - Raabe, Vanessa
AU - Cannavino, Christopher R.
AU - Hines, Andrea Green
AU - Bares, Sara H.
AU - Antiporta, Philip B.
AU - Scardina, Tonya
AU - Patel, Ursula
AU - Reid, Gail
AU - Mohazabnia, Parvin
AU - Kachhdiya, Suresh
AU - Le, Binh Minh
AU - Park, Connie J.
AU - Ostrowsky, Belinda E.
AU - Robicsek, Ari
AU - Smith, Becky A.
AU - Schied, Jeanmarie
AU - Bhatti, Micah M.
AU - Mayer, Stockton
AU - Sikka, Monica
AU - Murphy-Aguilu, Ivette
AU - Patwari, Priti
AU - Abeles, Shira R.
AU - Torriani, Francesca J.
AU - Abbas, Zainab
AU - Toya, Sophie
AU - Doktor, Katherine
AU - Chakrabarti, Anindita
AU - Doblecki-Lewis, Susanne
AU - Looney, David J.
AU - David, Michael Z.
N1 - Funding Information:
Financial support. National Institute of Allergy and Infectious Diseases (grant K23 AI095361 to M.Z.D.). Potential conflicts of interest. All authors report no conflicts of interest relevant to this article.
Publisher Copyright:
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved.
PY - 2015
Y1 - 2015
N2 - background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.
AB - background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.
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U2 - 10.1017/ice.2015.170
DO - 10.1017/ice.2015.170
M3 - Article
C2 - 26224364
AN - SCOPUS:84950158168
SN - 0899-823X
VL - 36
SP - 1251
EP - 1260
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
IS - 11
ER -
