TY - JOUR
T1 - Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity
AU - Schlabritz-Loutsevitch, Natalia E.
AU - Comuzzie, Anthony G.
AU - Mahaney, Michael M.
AU - Hubbard, Gene B.
AU - Dick, Edward J.
AU - Kocak, Mehmet
AU - Gupta, Sonali
AU - Carrillo, Maira
AU - Schenone, Mauro
AU - Postlethwaite, Arnold
AU - Slominski, Andrzej
N1 - Publisher Copyright:
Copyright 2016 by the American Association for Laboratory Animal Science.
PY - 2016/4
Y1 - 2016/4
N2 - Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.
AB - Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.
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M3 - Article
C2 - 27053568
AN - SCOPUS:84963935999
SN - 1532-0820
VL - 66
SP - 137
EP - 142
JO - Comparative Medicine
JF - Comparative Medicine
IS - 2
ER -