Serotonin-1D hypothesis of obsessive-compulsive disorder: An update

Joseph Zohar, James L. Kennedy, Eric Hollander, Lorrin M. Koran

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 14
StatePublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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