Serotonergic function in social phobia: Comparison to normal control and obsessive-compulsive disorder subjects

Eric Hollander; Jee Kwon; Fenia Weiller; Lisa Cohen; Dan J. Stein; Concetta DeCaria; Michael Liebowitz; Daphne Simeon

doi:10.1016/S0165-1781(98)00041-9

Serotonergic function in social phobia: Comparison to normal control and obsessive-compulsive disorder subjects

Eric Hollander, Jee Kwon, Fenia Weiller, Lisa Cohen, Dan J. Stein, Concetta DeCaria, Michael Liebowitz, Daphne Simeon

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Eighteen patients with social phobia, 21 normal control subjects, and 42 obsessive-compulsive disorder (OCD) control subjects were challenged with single doses of the partial serotonin agonist oral m-chlorophenylpiperazine (m-CPP) and placebo. Social phobics did not significantly differ from normal or OCD control subjects in prolactin response to m-CPP. There was a significant difference across groups in cortisol response to m-CPP, such that female social phobics had more robust cortisol responses to the m-CPP challenge. Pairwise comparisons only reached trend significance, perhaps due to the relatively small sample sizes. This study offers preliminary evidence for serotonin dysfunction in social phobia, particularly in female social phobics, but needs to be replicated in a larger sample size.

Original language	English (US)
Pages (from-to)	213-217
Number of pages	5
Journal	Psychiatry Research
Volume	79
Issue number	3
DOIs	https://doi.org/10.1016/S0165-1781(98)00041-9
State	Published - Jul 13 1998
Externally published	Yes

Keywords

Cortisol
Obsessive-compulsive disorder
Prolactin
Serotonin (5-HT)
Social phobia
m- CPP

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-1781(98)00041-9

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title = "Serotonergic function in social phobia: Comparison to normal control and obsessive-compulsive disorder subjects",

abstract = "Eighteen patients with social phobia, 21 normal control subjects, and 42 obsessive-compulsive disorder (OCD) control subjects were challenged with single doses of the partial serotonin agonist oral m-chlorophenylpiperazine (m-CPP) and placebo. Social phobics did not significantly differ from normal or OCD control subjects in prolactin response to m-CPP. There was a significant difference across groups in cortisol response to m-CPP, such that female social phobics had more robust cortisol responses to the m-CPP challenge. Pairwise comparisons only reached trend significance, perhaps due to the relatively small sample sizes. This study offers preliminary evidence for serotonin dysfunction in social phobia, particularly in female social phobics, but needs to be replicated in a larger sample size.",

keywords = "Cortisol, Obsessive-compulsive disorder, Prolactin, Serotonin (5-HT), Social phobia, m- CPP",

author = "Eric Hollander and Jee Kwon and Fenia Weiller and Lisa Cohen and Stein, {Dan J.} and Concetta DeCaria and Michael Liebowitz and Daphne Simeon",

note = "Funding Information: We acknowledge the helpful contributions of Franklin Schneier, M.D., Brian Fallon, M.D., and Raphael Campeas, M.D., to this study. Supported in part by Research Scientist Development Award MH-00750 (E. Hollander) from the NIMH, Bethesda, MD; the Seaver Foundation; and the Mount Sinai General Clinical Research Center from the National Center for Research Resources, NIH (M01 RR00071).",

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AU - Cohen, Lisa

AU - Stein, Dan J.

AU - DeCaria, Concetta

AU - Liebowitz, Michael

AU - Simeon, Daphne

N1 - Funding Information: We acknowledge the helpful contributions of Franklin Schneier, M.D., Brian Fallon, M.D., and Raphael Campeas, M.D., to this study. Supported in part by Research Scientist Development Award MH-00750 (E. Hollander) from the NIMH, Bethesda, MD; the Seaver Foundation; and the Mount Sinai General Clinical Research Center from the National Center for Research Resources, NIH (M01 RR00071).

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N2 - Eighteen patients with social phobia, 21 normal control subjects, and 42 obsessive-compulsive disorder (OCD) control subjects were challenged with single doses of the partial serotonin agonist oral m-chlorophenylpiperazine (m-CPP) and placebo. Social phobics did not significantly differ from normal or OCD control subjects in prolactin response to m-CPP. There was a significant difference across groups in cortisol response to m-CPP, such that female social phobics had more robust cortisol responses to the m-CPP challenge. Pairwise comparisons only reached trend significance, perhaps due to the relatively small sample sizes. This study offers preliminary evidence for serotonin dysfunction in social phobia, particularly in female social phobics, but needs to be replicated in a larger sample size.

AB - Eighteen patients with social phobia, 21 normal control subjects, and 42 obsessive-compulsive disorder (OCD) control subjects were challenged with single doses of the partial serotonin agonist oral m-chlorophenylpiperazine (m-CPP) and placebo. Social phobics did not significantly differ from normal or OCD control subjects in prolactin response to m-CPP. There was a significant difference across groups in cortisol response to m-CPP, such that female social phobics had more robust cortisol responses to the m-CPP challenge. Pairwise comparisons only reached trend significance, perhaps due to the relatively small sample sizes. This study offers preliminary evidence for serotonin dysfunction in social phobia, particularly in female social phobics, but needs to be replicated in a larger sample size.

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Serotonergic function in social phobia: Comparison to normal control and obsessive-compulsive disorder subjects

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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