Seronegative chronic relapsing neuroborreliosis

Christine Lawrence, Richard B. Lipton, Franklin D. Lowy, P. K. Coyle

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burg-dorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B, burgdorferi antibodies, B burgdorferi nucleic acids and free antigen.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalEuropean Neurology
Issue number2
StatePublished - 1995
Externally publishedYes


  • Herxheimer
  • Immune complex
  • Lyme disease, Seronegative

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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