TY - JOUR
T1 - Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus
AU - Chen, Tingting
AU - Mattila, Petri S.
AU - Jartti, Tuomas
AU - Ruuskanen, Olli
AU - Söderlund-Venermo, Maria
AU - Hedman, Klaus
N1 - Funding Information:
Financial support. This study was supported by the Helsinki University Central Hospital Research and Education and Research and Development Funds, the Sigrid Jusélius Foundation, the Medical Society of Finland, the Academy of Finland (project 1122539), and the Turku University Foundation (O. R.).
PY - 2011/11/15
Y1 - 2011/11/15
N2 - Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.
AB - Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.
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U2 - 10.1093/infdis/jir614
DO - 10.1093/infdis/jir614
M3 - Article
C2 - 21926381
AN - SCOPUS:80054729401
SN - 0022-1899
VL - 204
SP - 1523
EP - 1526
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -