Selected Rheumatologic and Dermatologic Manifestations of Inflammatory Bowel Disease

Beth Schorr‐Lesnick, Lawrence J. Brandt

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


This review focuses on the behavior and pathogenesis of selected dermatologic and rheumatologic manifestations of inflammatory bowel disease. Erythema nodosum, the most common skin lesion, correlates with activity of the bowel disease but not with its duration or extent. Resolution occurs with therapy of inflammatory bowel disease. Pyoderma gangrenosum, the most severe skin lesion, bears little relationship to the activity or extent of the colitis. Therapy is usually supportive, but dapsone and steroids appear promising. Immune and vasculitic mechanisms have been postulated for both skin lesions. Peripheral arthritis usually bas its onset with or after the development of colitic symptoms. It worsens with exacerbation of bowel inflammation and responds to treatment of the bowel disease. Immune mechanisms are likely. Spondyloarthropathy usually occurs before the onset of overt intestinal disease. Its course is unrelated to the bowel inflammation, it does not respond to treatment of bowel disease, and it is associated with HLA B27.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalThe American Journal of Gastroenterology
Issue number3
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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