Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization

Alfonso Oceguera, Andrea V. Peralta, Gustavo Martínez-Delgado, Carlos F. Arias, Susana López

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Cellular mRNAs cycle between translating and non-translating pools, polysomes compose the translating pool, while RNA granules contain translationally-silenced mRNAs, where the RNAs are either stored in stress granules, or accumulate in processing bodies (PBs) or GW-bodies, which have an important role in RNA degradation. Viruses have developed measures to prevent the deleterious effects of these structures during their replication. Rotavirus, the most common agent of viral gastroenteritis, is capable of establishing a successful infection by counteracting several of the antiviral responses of its host. Here, we describe that in rotavirus-infected cells the distribution of several RNA binding proteins is changed causing the disaggregation of PBs, the relocalization of GW-body proteins, and the cytoplasmic accumulation of HuR, a predominantly nuclear protein. We show that this redistribution of proteins is more likely caused by the accumulation of viral RNA in the cytoplasm of infected-cells, where it might be acting as an RBP sponge.

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
StatePublished - Dec 2018
Externally publishedYes


  • GW-bodies
  • P-bodies
  • RNA binding proteins
  • RNA granules
  • RNA sponges
  • Rotavirus
  • Virus host cell interactions

ASJC Scopus subject areas

  • Virology


Dive into the research topics of 'Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization'. Together they form a unique fingerprint.

Cite this