Role of vasoactive mediators in the pathogenesis of Chagas' disease

Shankar Mukherjee; Huan Huang; Louis M. Weiss; Sylvia Costa; Julio Scharfstein; Herbert B. Tanowitz

Role of vasoactive mediators in the pathogenesis of Chagas' disease

Shankar Mukherjee, Huan Huang, Louis M. Weiss, Sylvia Costa, Julio Scharfstein, Herbert B. Tanowitz

Pathology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Original language	English (US)
Pages (from-to)	e411-e420
Journal	Frontiers in Bioscience
Volume	8
State	Published - 2003

Keywords

Bradykinin
Chagas' disease
Endothelin
Kinins
Review
Trypanosoma cruzi

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Role of vasoactive mediators in the pathogenesis of Chagas' disease",

abstract = "This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.",

keywords = "Bradykinin, Chagas' disease, Endothelin, Kinins, Review, Trypanosoma cruzi",

author = "Shankar Mukherjee and Huan Huang and Weiss, {Louis M.} and Sylvia Costa and Julio Scharfstein and Tanowitz, {Herbert B.}",

year = "2003",

language = "English (US)",

volume = "8",

pages = "e411--e420",

journal = "Frontiers in Bioscience",

issn = "2768-6701",

publisher = "Frontiers in Bioscience",

}

TY - JOUR

T1 - Role of vasoactive mediators in the pathogenesis of Chagas' disease

AU - Mukherjee, Shankar

AU - Huang, Huan

AU - Weiss, Louis M.

AU - Costa, Sylvia

AU - Scharfstein, Julio

AU - Tanowitz, Herbert B.

PY - 2003

Y1 - 2003

N2 - This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

AB - This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

KW - Bradykinin

KW - Chagas' disease

KW - Endothelin

KW - Kinins

KW - Review

KW - Trypanosoma cruzi

UR - http://www.scopus.com/inward/record.url?scp=3142718318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142718318&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:3142718318

SN - 2768-6701

VL - 8

SP - e411-e420

JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

ER -

Role of vasoactive mediators in the pathogenesis of Chagas' disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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