Role of vasoactive mediators in the pathogenesis of Chagas' disease

Shankar Mukherjee, Huan Huang, Louis M. Weiss, Sylvia Costa, Julio Scharfstein, Herbert B. Tanowitz

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Original languageEnglish (US)
Pages (from-to)e411-e420
JournalFrontiers in Bioscience
StatePublished - 2003


  • Bradykinin
  • Chagas' disease
  • Endothelin
  • Kinins
  • Review
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Role of vasoactive mediators in the pathogenesis of Chagas' disease'. Together they form a unique fingerprint.

Cite this