Role of no synthase in the development of Trypanosoma craz/-induced cardiomyopathy in mice

Jorge L. Durand, Shankar Mukherjee, Fernando Commodari, Andrea P. De Souza, Dazhi Zhao, Fabiana S. Machado, Herbert B. Tanowitz, Linda A. Jelicks

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Trypanosoma cruzi infection results in an increase in myocardial NO and intense inflammation. NO modu-lates the T. craz/-induced myocardial inflammatory reaction. NO synthase (NOS)l-, NOS2-, and NOS3-null mice were infected with T. cruzi (Brazil strain). Infected NOSl-null mice had increased parasitemia, mortality, and left ventricular inner diameter (LVID). Chronically infected NOS1-and NOS2-null and wild-type mice (WT) exhibited increased right ventricular internal diameter (RVID), although the fold increase in the NOS2-null mice was smaller. Infected NOS3-null mice exhibited a significant reduction both in LVID and RVID. Reverse transcriptase-polymerase chain reaction showed expression of NOS2 and NOS3 in hearts of infected NOS1-null and WT mice, whereas infected NOS2-null hearts showed little change in expression of other NOS isoforms. Infected NOS3-null hearts showed an increase only in NOS1 expres-sion. These results may indicate different roles for NOS isoforms in T. cruzi-induced cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)782-787
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number5
StatePublished - May 2009
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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