Role of antiplatelet agents in hematoma expansion during the acute period of intracerebral hemorrhage

Michael Moussouttas, Rishi Malhotra, Luis Fernandez, Mitchell Maltenfort, Melissa Holowecki, Jennifer Delgado, Nadine Lawson, Neeraj Badjatia

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: Oral anticoagulants have been associated with greater hematoma expansion in patients with intracerebral hemorrhage (ICH). The purpose of this study was to determine whether the reported use of antiplatelet agents also results in greater hematoma expansion. Methods: Retrospective review of patients with spontaneous supratentorial ICH diagnosed within 6 h of onset, who underwent follow-up head CT approximately 48 h later. Digital imaging analysis of initial and second CT scans was performed for comparison of hematoma volume changes between patients reporting and those not reporting antecedent antiplatelet use. Statistical analyses to determine predictors of ICH volume change and in-hospital mortality were also performed via multivariate regression models. Results: Of the 70 patients included, 17 were documented as taking antiplatelet agents. Groups were comparable regarding baseline demographic, clinical and laboratory characteristics, and the timing of CT scans was similar. Patients reporting antiplatelet use experienced greater absolute increase (7.7 ml vs. 5.5 ml) and proportional increase (110% vs. 21%) in ICH volume than those not reporting antiplatelet use, but these differences were not statistically significant (P = 0.94 and 0.61 respectively; Wilcoxon test). Baseline hematoma volume tended to correlate with percentage volume increase (P < 0.1), whereas IVH was inversely associated with percent volume increase (P < 0.05). Age (P < 0.05), absolute volume increase (P < 0.005), and final volume (P < 0.001) were associated with in-hospital mortality, the rates of which were similar between the two study groups (18% vs. 17%). Conclusions: Patients reporting antiplatelet use experienced similar degrees of hematoma expansion compared to patients not reporting antiplatelet use.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalNeurocritical Care
Issue number1
StatePublished - Feb 1 2010
Externally publishedYes


  • Acute
  • Antiplatelet
  • Digital image analysis
  • Enlargement
  • Expansion
  • Hematoma
  • Hemorrhage
  • Intracerebral hemorrhage
  • Volume

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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