Role of adult hippocampal neurogenesis in persistent pain

A. Vania Apkarian, Amelia A. Mutso, Maria V. Centeno, Lixin Kan, Melody Wu, Marjorie Levinstein, Ghazal Banisadr, Kevin T. Gobeske, Richard J. Miller, Jelena Radulovic, René Hen, John A. Kessler

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.

Original languageEnglish (US)
Pages (from-to)418-428
Number of pages11
Issue number2
StatePublished - Feb 1 2016
Externally publishedYes


  • Inflammatory
  • Learning
  • Mood
  • Neurogenesis
  • Neuropathic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Role of adult hippocampal neurogenesis in persistent pain'. Together they form a unique fingerprint.

Cite this