TY - JOUR
T1 - RNA processing and export.
AU - Hocine, Sami
AU - Singer, Robert H.
AU - Grünwald, David
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
AB - Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
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U2 - 10.1101/cshperspect.a000752
DO - 10.1101/cshperspect.a000752
M3 - Review article
C2 - 20961978
AN - SCOPUS:79952578787
SN - 1943-0264
VL - 2
SP - a000752
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 12
ER -