Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration

Gregory E. Tong, Sant Kumar, Karen C. Chong, Nikita Shah, Margaret J. Wong, Jeffrey M. Zimmet, Zhen Jane Wang, Judy Yee, Yanjun Fu, Benjamin M. Yeh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose: To compare the incidence of contrast-induced nephropathy (CIN) for intravenous vs. intra-arterial administration of iodixanol, compared to non-administration. Methods: We retrospectively identified 650 patients who had intravenous iodixanol-enhanced CT, 695 with intra-arterial iodixanol cardiac catheterization, 651 with unenhanced CT, and those who also had baseline and follow-up serum creatinine within 5 days of the exam. From the medical records, we recorded the gender, age, baseline and follow-up serum creatinine/eGFR; underlying renal injury risk factors; indication for imaging; contrast material administration volume, concentration, and route of administration; and use of pre-imaging prophylactic measures for CIN. Univariate and multivariate models were used to determine predictors of CIN. Results: Baseline eGFR was lower for patients undergoing unenhanced CT than intravenous or intra-arterial patients (68 vs. 74.6 and 72.2, respectively, p < 0.01) and not different between intravenous and intra-arterial patients (p = 0.735). Simple logistic regression did not show a difference in the rate of CIN in patients who received intravenous vs. intra-arterial iodixanol (28 of 650, 4%, vs. 28 of 695, 4%, respectively, p = 0.798), nor a higher rate of CIN than seen with unenhanced CT (45 of 651, 7%, p = 0.99 and p = 0.98 by one-sided t test). Multivariate regression modeling showed that only elevated baseline creatinine or decreased eGFR and low hematocrit/hemoglobin were associated with CIN incidence (odds ratio 1.28 and 2.5; p < 0.023 and <0.006, respectively). Conclusions: Elevation in serum creatinine due to intravenous and intra-arterial iodixanol administration is infrequent and is not more common than after unenhanced CT scans.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalAbdominal Radiology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • CT
  • Cardiac catheterization
  • Contrast-induced nephropathy
  • Intra-arterial
  • Intravenous
  • Renal

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology


Dive into the research topics of 'Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration'. Together they form a unique fingerprint.

Cite this