TY - JOUR
T1 - Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles
AU - Ho, Gloria Y.F.
AU - Studentsov, Yevgeniy
AU - Hall, Charles B.
AU - Bierman, Robert
AU - Beardsley, Leah
AU - Lempa, Michele
AU - Burk, Robert D.
PY - 2002/9/15
Y1 - 2002/9/15
N2 - A high incidence of initial infection with human papillomavirus (HPV) was previously reported in a cohort of 608 women monitored at 6-month intervals for 3 years. Risk factors for subsequent infections with different HPV types and whether antibodies against HPV-16 virus-like particles (VLPs) protected against these infections were examined. Subsequent infections with HPV are very common. Seventy percent of women acquired a different HPV type within 24 months of the initial infection. Risk factors included being nonwhite, having an increased number of male sex partners, and having had a new male sex partner. Use of oral contraceptive pills was protective. A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58).
AB - A high incidence of initial infection with human papillomavirus (HPV) was previously reported in a cohort of 608 women monitored at 6-month intervals for 3 years. Risk factors for subsequent infections with different HPV types and whether antibodies against HPV-16 virus-like particles (VLPs) protected against these infections were examined. Subsequent infections with HPV are very common. Seventy percent of women acquired a different HPV type within 24 months of the initial infection. Risk factors included being nonwhite, having an increased number of male sex partners, and having had a new male sex partner. Use of oral contraceptive pills was protective. A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58).
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U2 - 10.1086/342972
DO - 10.1086/342972
M3 - Article
C2 - 12198606
AN - SCOPUS:0037105643
SN - 0022-1899
VL - 186
SP - 737
EP - 742
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -