Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels

Rupinder Singh Buttar; Jasveen Batra; Jacqueline Kreimerman; Melissa Aleta; Michal L. Melamed

doi:10.1007/s11606-017-4115-x

Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels

Rupinder Singh Buttar, Jasveen Batra, Jacqueline Kreimerman, Melissa Aleta, Michal L. Melamed

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.

Original language	English (US)
Pages (from-to)	1156-1159
Number of pages	4
Journal	Journal of general internal medicine
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s11606-017-4115-x
State	Published - Oct 1 2017

Keywords

acute kidney injury
drug interaction
rhabdomyolysis
sitagliptin
statins
vitamin D

ASJC Scopus subject areas

Internal Medicine

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10.1007/s11606-017-4115-x

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AU - Aleta, Melissa

AU - Melamed, Michal L.

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AB - We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.

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Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels

Abstract

Keywords

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