Review of current neurotoxicology biomarkers

Marcell Valandro Soares, Flavia Suelen de Oliveira Pereira, Daiana Silva Avila, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Environmental and occupational exposure to chemical and biological agents can interfere with neurons and glial cells from the central and peripheral nervous systems and generate a condition called neurotoxicity. Early diagnostics is critical to improve outcomes and to avoid long-lasting damage that can incapacitate the affected subjects. To that end, clinical biomarkers of exposure, effect, and susceptibility have been applied using different biological matrices. Biomarkers must be specific, sensitive, and less invasive as possible; however, the literature demonstrates that neurotoxicity biomarkers are still on the path of validation. This chapter focuses on biomarkers that have been validated in humans and are clinically used and those that are being investigated and seem promising. We will address different types of biomarkers for a variety of toxicants and then focus on three major classes: metals, pesticides, and organic solvents. Our literature compilation indicates that just a few biomarkers follow the desired characteristics and that the development of neurotoxicity biomarkers must be a shared goal from scientists from different disciplines in order to advance in this field.

Original languageEnglish (US)
Title of host publicationToxicological Risk Assessment and Multi-System Health Impacts from Exposure
Number of pages17
ISBN (Electronic)9780323852159
StatePublished - Jan 1 2021


  • Biomarkers
  • Metals
  • Neurotoxicity
  • Organic solvents
  • Pesticides

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Review of current neurotoxicology biomarkers'. Together they form a unique fingerprint.

Cite this