Reverse yeast two-hybrid system to identify mammalian nuclear receptor residues that interact with Ligands and/or antagonists

Engineering & Materials Science

• Cytoplasmic and Nuclear Receptors 100%
• Ligands 69%
• Yeast 62%
• Assays 61%
• Hybrid systems 51%
• Binding sites 24%
• Metabolism 22%
• Proteins 16%
• Throughput 12%
• Proteomics 11%

Medicine & Life Sciences

• Pregnane X Receptor 76%
• Two-Hybrid System Techniques 67%
• Ketoconazole 56%
• Cytoplasmic and Nuclear Receptors 54%
• Ligands 37%
• Yeasts 24%
• Pharmaceutical Preparations 12%
• Furylfuramide 12%
• Binding Sites 11%
• Gain of Function Mutation 9%
• Inflammation 8%
• Mutation 8%
• Proteomics 6%
• Libraries 6%
• Clone Cells 6%
• Proteins 5%
• Liver 3%

Chemical Compounds

• Pregnane 77%
• Antagonist 49%
• Ligand 23%
• Mutation 19%
• Drug 11%
• Pharmacological Metabolism 11%
• Binding Site 10%
• Agonist 7%
• Surface 7%
• Protein 6%