Reversal agents

Andrew Sim, Angela Vick

Research output: Chapter in Book/Report/Conference proceedingChapter


One of the clinical indications for administering cholinesterase inhibitors, or anticholinesterases, is to reverse the effect of muscle relaxation by non-depolarizing neuromuscular blocking agents at the conclusion of surgery. The purpose of administering antimuscarinic drugs concomitantly with anticholinesterases is to minimize the muscarinic side effects associated with increased acetylcholine transmission at muscarinic receptors. In this chapter, we review anticholinesterase and anticholinergic pharmacology, including mechanism of action, dosing, and adverse effects. We discuss their clinical significance in both the surgical context and their indications outside the operating room. In addition, we briefly discuss the relaxant binding agent sugammadex and its future role in anesthesia.

Original languageEnglish (US)
Title of host publicationEssentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care
PublisherSpringer New York
Number of pages14
ISBN (Electronic)9781461489481
ISBN (Print)9781461489474
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Reversal agents'. Together they form a unique fingerprint.

Cite this