Retinoids and the prevention of cervical dysplasias

S. L. Romney; P. R. Palan; C. Duttagupta; S. Wassertheil-Smoller; J. Wylie; G. Miller; N. S. Slagle; D. Lucido

doi:10.1016/S0002-9378(16)32680-1

Retinoids and the prevention of cervical dysplasias

S. L. Romney, P. R. Palan, C. Duttagupta, S. Wassertheil-Smoller, J. Wylie, G. Miller, N. S. Slagle, D. Lucido

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.

Original language	English (US)
Pages (from-to)	890-894
Number of pages	5
Journal	Unknown Journal
Volume	141
Issue number	8
DOIs	https://doi.org/10.1016/S0002-9378(16)32680-1
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/S0002-9378(16)32680-1

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title = "Retinoids and the prevention of cervical dysplasias",

abstract = "Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.",

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T1 - Retinoids and the prevention of cervical dysplasias

AU - Romney, S. L.

AU - Palan, P. R.

AU - Duttagupta, C.

AU - Wassertheil-Smoller, S.

AU - Wylie, J.

AU - Miller, G.

AU - Slagle, N. S.

AU - Lucido, D.

PY - 1981

Y1 - 1981

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AB - Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.

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Retinoids and the prevention of cervical dysplasias

Abstract

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