@article{0f3dd48a32194a77a4762f1205c186cc,
title = "Resolution of impaired multisensory processing in autism and the cost of switching sensory modality",
abstract = "Children with autism spectrum disorders (ASD) exhibit alterations in multisensory processing, which may contribute to the prevalence of social and communicative deficits in this population. Resolution of multisensory deficits has been observed in teenagers with ASD for complex, social speech stimuli; however, whether this resolution extends to more basic multisensory processing deficits remains unclear. Here, in a cohort of 364 participants we show using simple, non-social audiovisual stimuli that deficits in multisensory processing observed in high-functioning children and teenagers with ASD are not evident in adults with the disorder. Computational modelling indicated that multisensory processing transitions from a default state of competition to one of facilitation, and that this transition is delayed in ASD. Further analysis revealed group differences in how sensory channels are weighted, and how this is impacted by preceding cross-sensory inputs. Our findings indicate that there is a complex and dynamic interplay among the sensory systems that differs considerably in individuals with ASD.",
author = "Crosse, {Michael J.} and Foxe, {John J.} and Katy Tarrit and Freedman, {Edward G.} and Sophie Molholm",
note = "Funding Information: The authors thank Juliana Bates, Natalie Russo, and the Human Clinical Phenotyping Core (HCP) for their careful clinical and cognitive phenotyping of our ASD cohort, Alice Brandwein who conducted the previous research for which most of these data were collected, Cristiano Cuppini for his helpful comments and discussions, Ana Francisco for her support with statistical analyses, Douwe Horsthuis for his technical support and data collection, and Elise Taverna and Danielle DeMaio for their technical assistance. We also extend our heartfelt gratitude to the participants and their families that have contributed their time to participate in this research. This work was supported by the National Institute of Mental Health of the National Institutes of Health (NIH) under award number R01MH085322 (S.M. and J.J.F.), and the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the NIH under award number U54HD090260, previously P30HD071593 (Rose F. Kennedy Intellectual and Developmental Disabilities Research Center). Participant recruitment and phenotyping for participants at the University of Rochester was conducted through the UR-IDDRC Human Clinical Phenotyping and Recruitment Core, supported by a centre grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development under the award number P50HD103536 (J.J.F.). Data collection for this project at the University of Rochester was supported though a pilot grant from the Harry T. Mangurian, Jr. Foundation (E.G.F., S.M. and J.J.F.). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s42003-022-03519-1",
language = "English (US)",
volume = "5",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",
}