Repolarization Remodeling in Structural Heart Disease

Andreas S. Barth; Gordon F. Tomaselli

doi:10.1007/978-3-030-22672-5_3

Repolarization Remodeling in Structural Heart Disease

Andreas S. Barth, Gordon F. Tomaselli

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Structural heart disease is associated with both alterations in mechanical function and electrical remodeling; the latter may enhance the risk of lethal ventricular arrhythmias. Prominently among the many changes in hypertrophied and failing hearts is delayed and labile repolarization that exaggerates the spatial and temporal dispersion of electrical recovery. The changes in repolarization involve alterations in heterogeneous changes in depolarizing and repolarizing ionic currents as well as alterations in calcium homeostasis. These changes in active membrane properties often occur in the setting of compromised conduction in the myocardium further increasing the risk of ventricular arrhythmias and sudden cardiac death (SCD). We present a brief overview of ionic current remodeling that underlies the arrhythmogenic changes observed in heart failure.

Original language	English (US)
Title of host publication	Cardiac Repolarization
Subtitle of host publication	Basic Science and Clinical Management
Publisher	Springer International Publishing
Pages	77-85
Number of pages	9
ISBN (Electronic)	9783030226725
ISBN (Print)	9783030226718
DOIs	https://doi.org/10.1007/978-3-030-22672-5_3
State	Published - Jan 1 2019

Keywords

Action potential
Arrhythmia
Calcium
Heart failure
Ion channels
Metabolism
Sudden death

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-030-22672-5_3

Cite this

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AB - Structural heart disease is associated with both alterations in mechanical function and electrical remodeling; the latter may enhance the risk of lethal ventricular arrhythmias. Prominently among the many changes in hypertrophied and failing hearts is delayed and labile repolarization that exaggerates the spatial and temporal dispersion of electrical recovery. The changes in repolarization involve alterations in heterogeneous changes in depolarizing and repolarizing ionic currents as well as alterations in calcium homeostasis. These changes in active membrane properties often occur in the setting of compromised conduction in the myocardium further increasing the risk of ventricular arrhythmias and sudden cardiac death (SCD). We present a brief overview of ionic current remodeling that underlies the arrhythmogenic changes observed in heart failure.

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KW - Ion channels

KW - Metabolism

KW - Sudden death

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Repolarization Remodeling in Structural Heart Disease

Abstract

Keywords

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