TY - JOUR
T1 - Renal tubular defects from antidepressant use in an older adult
T2 - An uncommon but reversible adverse drug effect
AU - Adiga, Giridhar U.
AU - Dharmarajan, T. S.
PY - 2006
Y1 - 2006
N2 - Adverse drug reactions are common and contribute to significant mortality and morbidity. We report a case study of an elderly woman who manifested with uncommon reversible renal tubular defects following the use of escitalopram. She was initially seen for worsening symptoms of depression and started on escitalopram in addition to her regular medications, which included donepezil, hydrochlorothiazide and mirtazapine. Three weeks later, she became increasingly confused and manifested recurrent falls. Laboratory evaluation showed hyponatraemia and evidence of renal tubular absorption defects. The patient's symptoms and laboratory abnormalities improved upon discontinuation of escitalopram as well as of mirtazapine and hydrochlorthiazide. This case illustrates the possibility of rare but reversible renal tubular defects associated with the use of antidepressant medications.
AB - Adverse drug reactions are common and contribute to significant mortality and morbidity. We report a case study of an elderly woman who manifested with uncommon reversible renal tubular defects following the use of escitalopram. She was initially seen for worsening symptoms of depression and started on escitalopram in addition to her regular medications, which included donepezil, hydrochlorothiazide and mirtazapine. Three weeks later, she became increasingly confused and manifested recurrent falls. Laboratory evaluation showed hyponatraemia and evidence of renal tubular absorption defects. The patient's symptoms and laboratory abnormalities improved upon discontinuation of escitalopram as well as of mirtazapine and hydrochlorthiazide. This case illustrates the possibility of rare but reversible renal tubular defects associated with the use of antidepressant medications.
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U2 - 10.2165/00044011-200626100-00008
DO - 10.2165/00044011-200626100-00008
M3 - Article
C2 - 17163295
AN - SCOPUS:33748796949
SN - 1173-2563
VL - 26
SP - 607
EP - 610
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
IS - 10
ER -