Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels

Juan A. Orellana, Kurt A. Schalper, Vania Figueroa, Helmuth A. Sánchez, Juan C. Sáez

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Scopus citations


The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins that constitute the molecular basis of two kinds of channels: gap junction channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and hemichannels (HCs) that provide a pathway for exchanges between the intra and extra-cellular milieu. Both kind of connexin-based channels support intercellular communication via intercellular propagation of calcium waves. Here, we review evidence supporting the role of Ca 2+ in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca 2+ signals.

Original languageEnglish (US)
Title of host publicationCalcium Signaling
Number of pages18
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Calcium waves
  • Calmodulin
  • Connexons
  • Dye coupling
  • Gap junctions
  • Hemichannels

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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