Regulation of hematopoiesis by growth factors

E. Richard Stanley

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The history of the role of hematopoietic growth factors (HGFs) in the regulation of hematopoiesis is briefly reviewed, commencing with the studies that defined the hematopoietic stem cell and led to the development of in vitro assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the "permissive" versus "instructive" models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor-1 (CSF-1), is reviewed, including its function in development as revealed by studies of mouse mutants and its role in innate immunity, inflammatory disease and cancer.

Original languageEnglish (US)
Title of host publicationStem Cells and their Potential for Clinical Application
EditorsNadia Bilko
Number of pages13
StatePublished - 2008

Publication series

NameNATO Security through Science Series C: Environmental Security
ISSN (Print)1871-4668


  • Blood cells
  • CSF-1
  • Macrophages
  • Osteoclasts
  • Review

ASJC Scopus subject areas

  • General Environmental Science


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