Registration of real-time 3-D ultrasound images of the heart for novel 3-D stress echocardiography

Raj Shekhar, Vladimir Zagrodsky, Mario J. Garcia, James D. Thomas

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Stress echocardiography is a routinely used clinical procedure to diagnose cardiac dysfunction by comparing wall motion information in prestress and poststress ultrasound images. Incomplete data, complicated imaging protocols and misaligned prestress and poststress views, however, are known limitations of conventional stress echocardiography. We discuss how the first two limitations are overcome via the use of real-time three-dimensional (3-D) ultrasound imaging, an emerging modality, and have called the new procedure "3-D stress echocardiography." We also show that the problem of misaligned views can be solved by registration of prestress and poststress 3-D image sequences. Such images are misaligned because of variations in placing the ultrasound transducer and stress-induced anatomical changes. We have developed a technique to temporally align 3-D images of the two sequences first and then to spatially register them to rectify probe placement error while preserving the stress-induced changes. The 3-D spatial registration is mutual information-based. Image registration used in conjunction with 3-D stress echocardiography can potentially improve the diagnostic accuracy of stress testing.

Original languageEnglish (US)
Pages (from-to)1141-1149
Number of pages9
JournalIEEE Transactions on Medical Imaging
Issue number9
StatePublished - Sep 2004
Externally publishedYes


  • Image registration
  • Mutual information
  • Stress echocardiography
  • Three-dimensional ultrasound imaging

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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