Refractory obsessive-compulsive disorder: State-of-the-art treatment

Eric Hollander, Carol A. Bienstock, Lorrin M. Koran, Stefano Pallanti, Donatella Marazziti, Steven A. Rasmussen, Luigi Ravizza, Chawkie Benkelfat, Sanjaya Saxena, Benjamin D. Greenberg, Yehuda Sasson, Joseph Zohar

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


Nonresponse to treatment in obsessive-compulsive disorder is common, associated with substantial impairment, and understudied. Little practical advice is available to clinicians on next-step treatment strategies for patients who have not responded well to 2 trials of selective serotonin reuptake inhibitors (SSRIs). Available options include continuation of SSRI treatment, switching to another SSRI or selective serotonin-norepinephrine reuptake inhibitor, augmenting with atypical neuroleptics or cognitive-behavioral therapy, or utilizing novel treatment approaches. The authors synthesize state-of-the-art treatment and give practical advice for clinicians.

Original languageEnglish (US)
Pages (from-to)20-29
Number of pages10
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 6
StatePublished - May 6 2002
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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