Reductive ligation mediated one-step disulfide formation of S -nitrosothiols

Jiming Zhang, Sheng Li, Dehui Zhang, Hua Wang, A. Richard Whorton, Ming Xian

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.

Original languageEnglish (US)
Pages (from-to)4208-4211
Number of pages4
JournalOrganic Letters
Issue number18
StatePublished - Sep 17 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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