Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Peer Dar; Dvora Strassburger; Aviv Shaish; Hannah Levkovitz; Reuvit Halperin; Dror Harats

doi:10.1159/000052934

Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Peer Dar, Dvora Strassburger, Aviv Shaish, Hannah Levkovitz, Reuvit Halperin, Dror Harats

Obstetrics & Gynecology and Women's Health

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R^-/-) and reproduction was compared to LDL-R^-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R^-/- mice as compared to the LDL-R^-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R^-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

Original language	English (US)
Pages (from-to)	18-21
Number of pages	4
Journal	Gynecologic and Obstetric Investigation
Volume	52
Issue number	1
DOIs	https://doi.org/10.1159/000052934
State	Published - 2001

Keywords

15-Lipoxygenase
Oxidized LDL
Reproduction
Spontaneous abortions
Transgenic mice

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1159/000052934

Cite this

@article{50c2c1517fa84f3c8c7aa67e3b6c9501,

title = "Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase",

abstract = "15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.",

keywords = "15-Lipoxygenase, Oxidized LDL, Reproduction, Spontaneous abortions, Transgenic mice",

author = "Peer Dar and Dvora Strassburger and Aviv Shaish and Hannah Levkovitz and Reuvit Halperin and Dror Harats",

year = "2001",

doi = "10.1159/000052934",

language = "English (US)",

volume = "52",

pages = "18--21",

journal = "Gynecologic and Obstetric Investigation",

issn = "0378-7346",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

AU - Dar, Peer

AU - Strassburger, Dvora

AU - Shaish, Aviv

AU - Levkovitz, Hannah

AU - Halperin, Reuvit

AU - Harats, Dror

PY - 2001

Y1 - 2001

N2 - 15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

AB - 15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions.

KW - 15-Lipoxygenase

KW - Oxidized LDL

KW - Reproduction

KW - Spontaneous abortions

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=0034828376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034828376&partnerID=8YFLogxK

U2 - 10.1159/000052934

DO - 10.1159/000052934

M3 - Article

C2 - 11549858

AN - SCOPUS:0034828376

SN - 0378-7346

VL - 52

SP - 18

EP - 21

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

IS - 1

ER -

Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this