TY - JOUR
T1 - Reduced Circulating Concentration of Brain-derived Neurotrophic Factor is Associated with Peri- and Post-implantation Failure following In Vitro Fertilization-Embryo Transfer
AU - Ramer, Ilana
AU - Kruczek, Alexis
AU - Doulaveris, Georgios
AU - Orfanelli, Theofano
AU - Shulman, Brittney
AU - Witkin, Steven S.
AU - Spandorfer, Steven D.
N1 - Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Problem: We evaluated associations between brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) and pregnancy outcome in women undergoing in vitro fertilization-embryo transfer (IVF-ET). Method of study: Sera obtained on days 24 and 28 of an IVF cycle from women with a live birth, spontaneous abortion, biochemical pregnancy, not pregnant, or an ectopic pregnancy were retrospectively analyzed for BDNF and NT4 by ELISA. Results: Median BDNF levels were higher in women with a live birth compared to women with an ectopic pregnancy (P < 0.0001), spontaneous abortion (P < 0.0001), or a biochemical pregnancy (P = 0.0004), but not in women who did not become pregnant. NT4 was detected in <25% of sera and did not differ by outcome. There was no association between BDNF level and oocyte or pre-transfer embryo parameters. Conclusion: Decreased circulating BDNF early in an IVF cycle is associated with adverse peri- and/or post-implantation events and subsequent pregnancy failure.
AB - Problem: We evaluated associations between brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) and pregnancy outcome in women undergoing in vitro fertilization-embryo transfer (IVF-ET). Method of study: Sera obtained on days 24 and 28 of an IVF cycle from women with a live birth, spontaneous abortion, biochemical pregnancy, not pregnant, or an ectopic pregnancy were retrospectively analyzed for BDNF and NT4 by ELISA. Results: Median BDNF levels were higher in women with a live birth compared to women with an ectopic pregnancy (P < 0.0001), spontaneous abortion (P < 0.0001), or a biochemical pregnancy (P = 0.0004), but not in women who did not become pregnant. NT4 was detected in <25% of sera and did not differ by outcome. There was no association between BDNF level and oocyte or pre-transfer embryo parameters. Conclusion: Decreased circulating BDNF early in an IVF cycle is associated with adverse peri- and/or post-implantation events and subsequent pregnancy failure.
KW - Brain-derived neurotrophic factor
KW - IVF outcome
KW - Implantation
KW - Neurotrophic factor 4
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U2 - 10.1111/aji.12430
DO - 10.1111/aji.12430
M3 - Article
C2 - 26547395
AN - SCOPUS:84955075544
SN - 1046-7408
VL - 75
SP - 36
EP - 41
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 1
ER -