TY - JOUR
T1 - Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women
AU - Kabat, Geoffrey C.
AU - Kim, Mimi
AU - Wactawski-Wende, Jean
AU - Lane, Dorothy
AU - Adams-Campbell, Lucile L.
AU - Gaudet, Mia
AU - Stefanick, Marcia L.
AU - Vitolins, Mara
AU - Chlebowski, Rowan T.
AU - Wassertheil-Smoller, Sylvia
AU - Rohan, Thomas E.
PY - 2010/12
Y1 - 2010/12
N2 - Objective: To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast. Methods: The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, the hazard ratio for DCIS among women with ≥20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS. Conclusions: Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.
AB - Objective: To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast. Methods: The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: After adjustment for covariates, the hazard ratio for DCIS among women with ≥20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS. Conclusions: Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.
KW - Body mass index
KW - Breast cancer
KW - Ductal carcinoma in situ
KW - Physical activity
KW - Waist circumference
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U2 - 10.1007/s10552-010-9637-z
DO - 10.1007/s10552-010-9637-z
M3 - Article
C2 - 20814736
AN - SCOPUS:78751574218
SN - 0957-5243
VL - 21
SP - 2173
EP - 2181
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -