Recent aspects of mammalian fertilization research

Paul M. Wassarman, Luca Jovine, Huayu Qi, Zev Williams, Costel Darie, Eveline S. Litscher

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Mammalian fertilization has been the subject of intensified research in recent times. Application of recombinant DNA, transgenic and gene targeting technology, in particular, to issues in mammalian fertilization has revolutionized the field. Here, we present some of the latest results coming from application of these and other technologies to four aspects of mammalian fertilization: 1. formation of the egg zona pellucida (ZP) during oocyte growth; 2. species-specific binding of sperm to the egg zona pellucida; 3. induction of the sperm acrosome reaction (AR) by the egg zona pellucida; 4. binding of sperm to and fusion with egg plasma membrane. In virtually every instance, new information and new insights have come from relatively recent investigations.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalMolecular and Cellular Endocrinology
Issue number1-2
StatePublished - Apr 29 2005
Externally publishedYes


  • Acrosome
  • Egg
  • Fertilization
  • Sperm
  • Zona pellucida

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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