Re-inventing adherence: Toward a patient-centered model of care for drug-resistant tuberculosis and HIV

M. R. O'Donnell; A. Daftary; M. Frick; Y. Hirsch-Moverman; K. R. Amico; M. Senthilingam; A. Wolf; J. Z. Metcalfe; P. Isaakidis; J. L. Davis; J. R. Zelnick; J. C.M. Brust; N. Naidu; M. Garretson; D. R. Bangsberg; N. Padayatchi; G. Friedland

doi:10.5588/ijtld.15.0360

Re-inventing adherence: Toward a patient-centered model of care for drug-resistant tuberculosis and HIV

M. R. O'Donnell, A. Daftary, M. Frick, Y. Hirsch-Moverman, K. R. Amico, M. Senthilingam, A. Wolf, J. Z. Metcalfe, P. Isaakidis, J. L. Davis, J. R. Zelnick, J. C.M. Brust, N. Naidu, M. Garretson, D. R. Bangsberg, N. Padayatchi, G. Friedland

Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

BACKGROUND: Despite renewed focus on molecular tuberculosis (TB) diagnostics and new antimycobacterial agents, treatment outcomes for patients co-infected with drug-resistant TB and human immunodeficiency virus (HIV) remain dismal, in part due to lack of focus on medication adherence as part of a patient-centered continuum of care. OBJECTIVE : To review current barriers to drug-resistant TB-HIV treatment and propose an alternative model to conventional approaches to treatment support. DISCUS S ION: Current national TB control programs rely heavily on directly observed therapy (DOT) as the centerpiece of treatment delivery and adherence support. Medication adherence and care for drug-resistant TBHIV could be improved by fully implementing teambased patient-centered care, empowering patients through counseling and support, maintaining a rightsbased approach while acknowledging the responsibility of health care systems in providing comprehensive care, and prioritizing critical research gaps. CONCLUS ION: It is time to re-invent our understanding of adherence in drug-resistant TB and HIV by focusing attention on the complex clinical, behavioral, social, and structural needs of affected patients and communities.

Original language	English (US)
Pages (from-to)	430-434
Number of pages	5
Journal	International Journal of Tuberculosis and Lung Disease
Volume	20
Issue number	4
DOIs	https://doi.org/10.5588/ijtld.15.0360
State	Published - Apr 1 2016

Keywords

Drug-resistant TB
HIV
Medication adherence
Patient-centered care

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.15.0360

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O'Donnell, M. R., Daftary, A., Frick, M., Hirsch-Moverman, Y., Amico, K. R., Senthilingam, M., Wolf, A., Metcalfe, J. Z., Isaakidis, P., Davis, J. L., Zelnick, J. R., Brust, J. C. M., Naidu, N., Garretson, M., Bangsberg, D. R., Padayatchi, N., & Friedland, G. (2016). Re-inventing adherence: Toward a patient-centered model of care for drug-resistant tuberculosis and HIV. International Journal of Tuberculosis and Lung Disease, 20(4), 430-434. https://doi.org/10.5588/ijtld.15.0360

O'Donnell, MR, Daftary, A, Frick, M, Hirsch-Moverman, Y, Amico, KR, Senthilingam, M, Wolf, A, Metcalfe, JZ, Isaakidis, P, Davis, JL, Zelnick, JR, Brust, JCM, Naidu, N, Garretson, M, Bangsberg, DR, Padayatchi, N & Friedland, G 2016, 'Re-inventing adherence: Toward a patient-centered model of care for drug-resistant tuberculosis and HIV', International Journal of Tuberculosis and Lung Disease, vol. 20, no. 4, pp. 430-434. https://doi.org/10.5588/ijtld.15.0360

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abstract = "BACKGROUND: Despite renewed focus on molecular tuberculosis (TB) diagnostics and new antimycobacterial agents, treatment outcomes for patients co-infected with drug-resistant TB and human immunodeficiency virus (HIV) remain dismal, in part due to lack of focus on medication adherence as part of a patient-centered continuum of care. OBJECTIVE : To review current barriers to drug-resistant TB-HIV treatment and propose an alternative model to conventional approaches to treatment support. DISCUS S ION: Current national TB control programs rely heavily on directly observed therapy (DOT) as the centerpiece of treatment delivery and adherence support. Medication adherence and care for drug-resistant TBHIV could be improved by fully implementing teambased patient-centered care, empowering patients through counseling and support, maintaining a rightsbased approach while acknowledging the responsibility of health care systems in providing comprehensive care, and prioritizing critical research gaps. CONCLUS ION: It is time to re-invent our understanding of adherence in drug-resistant TB and HIV by focusing attention on the complex clinical, behavioral, social, and structural needs of affected patients and communities.",

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AB - BACKGROUND: Despite renewed focus on molecular tuberculosis (TB) diagnostics and new antimycobacterial agents, treatment outcomes for patients co-infected with drug-resistant TB and human immunodeficiency virus (HIV) remain dismal, in part due to lack of focus on medication adherence as part of a patient-centered continuum of care. OBJECTIVE : To review current barriers to drug-resistant TB-HIV treatment and propose an alternative model to conventional approaches to treatment support. DISCUS S ION: Current national TB control programs rely heavily on directly observed therapy (DOT) as the centerpiece of treatment delivery and adherence support. Medication adherence and care for drug-resistant TBHIV could be improved by fully implementing teambased patient-centered care, empowering patients through counseling and support, maintaining a rightsbased approach while acknowledging the responsibility of health care systems in providing comprehensive care, and prioritizing critical research gaps. CONCLUS ION: It is time to re-invent our understanding of adherence in drug-resistant TB and HIV by focusing attention on the complex clinical, behavioral, social, and structural needs of affected patients and communities.

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Re-inventing adherence: Toward a patient-centered model of care for drug-resistant tuberculosis and HIV

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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