@article{6e75756c1bf142ddbf0f837a814d762d,
title = "Rapid calibration of an intracortical brain-computer interface for people with tetraplegia",
abstract = "Objective. Brain-computer interfaces (BCIs) can enable individuals with tetraplegia to communicate and control external devices. Though much progress has been made in improving the speed and robustness of neural control provided by intracortical BCIs, little research has been devoted to minimizing the amount of time spent on decoder calibration. Approach. We investigated the amount of time users needed to calibrate decoders and achieve performance saturation using two markedly different decoding algorithms: the steady-state Kalman filter, and a novel technique using Gaussian process regression (GP-DKF). Main results. Three people with tetraplegia gained rapid closed-loop neural cursor control and peak, plateaued decoder performance within 3 min of initializing calibration. We also show that a BCI-na{\"i}ve user (T5) was able to rapidly attain closed-loop neural cursor control with the GP-DKF using self-selected movement imagery on his first-ever day of closed-loop BCI use, acquiring a target 37 s after initiating calibration. Significance. These results demonstrate the potential for an intracortical BCI to be used immediately after deployment by people with paralysis, without the need for user learning or extensive system calibration.",
keywords = "Gaussian process regression, Kalman filtering, brain-computer interfaces, discriminative Kalman filter, neural decoding",
author = "Brandman, {David M.} and Tommy Hosman and Jad Saab and Burkhart, {Michael C.} and Shanahan, {Benjamin E.} and Ciancibello, {John G.} and Sarma, {Anish A.} and Milstein, {Daniel J.} and Vargas-Irwin, {Carlos E.} and Brian Franco and Jessica Kelemen and Christine Blabe and Murphy, {Brian A.} and Young, {Daniel R.} and Willett, {Francis R.} and Chethan Pandarinath and Stavisky, {Sergey D.} and Kirsch, {Robert F.} and Walter, {Benjamin L.} and {Bolu Ajiboye}, A. and Cash, {Sydney S.} and Eskandar, {Emad N.} and Miller, {Jonathan P.} and Sweet, {Jennifer A.} and Shenoy, {Krishna V.} and Henderson, {Jaimie M.} and Beata Jarosiewicz and Harrison, {Matthew T.} and Simeral, {John D.} and Hochberg, {Leigh R.}",
note = "Funding Information: This work was supported by the National Institutes of Health: National Institute on Deafness and Other Communication Disorders-NIDCD (R01DC009899, R01DC014034), Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Center for Medical Rehabilitation Research-NICHD/NCMRR (R01HD077220); Rehabilitation Research and Development Service, Department of Veterans Affairs (B6453R, A6779I, N9228C, B4853C); National Science Foundation (1309004); Massachusetts General Hospital (MGH)-Deane Institute for Integrated Research on Atrial Fibrillation and Stroke; Joseph Martin Prize for Basic Research; The Executive Committee on Research (ECOR) of Massachusetts General Hospital; Stanford Institute for Neuro-Innovation and Translational Neuroscience; Stanford BioX-NeuroVentures; Stanford Office of Postdoctoral Affairs; ALSA Milton Safenowitz Postdoctoral Fellowship; Garlick Foundation; Katie Samson Foundation; Craig H Neilsen Foundation; Canadian Institute of Health Research (336092); Killam Trust Award Foundation; Brown Institute of Brain Science. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the Department of Veterans Affairs or the United States Government. Funding Information: The authors would like to thank participants T5, T8, T10, and their families; B Travers, and D Rosler for administrative support; S K Miller for manuscript editing; L Barefoot, C Grant, M Bowker, and S Mernoff for clinical assistance; L Ball for references; and M Vilela, P Nuyujukian, J P Donoghue for helpful scientific discussions. This work was supported by the National Institutes of Health: National Institute on Deafness and Other Communication Disorders—NIDCD (R01DC009899, R01DC014034), Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Center for Medical Rehabilitation Research—NICHD/NCMRR (R01HD077220); Rehabilitation Research and Development Service, Department of Veterans Affairs (B6453R, A6779I, N9228C, B4853C); National Science Foundation (1309004); Massachusetts General Hospital (MGH)—Deane Institute for Integrated Research on Atrial Fibrillation and Stroke; Joseph Martin Prize for Basic Research; The Executive Committee on Research (ECOR) of Massachusetts General Hospital; Stanford Institute for Neuro-Innovation and Translational Neuroscience; Stanford BioX-NeuroVentures; Stanford Office of Postdoctoral Affairs; ALSA Milton Safenowitz Postdoctoral Fellowship; Garlick Foundation; Katie Samson Foundation; Craig H Neilsen Foundation; Canadian Institute of Health Research (336092); Killam Trust Award Foundation; Brown Institute of Brain Science. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the Department of Veterans Affairs or the United States Government. Publisher Copyright: {\textcopyright} 2018 IOP Publishing Ltd.",
year = "2018",
month = jan,
day = "24",
doi = "10.1088/1741-2552/aa9ee7",
language = "English (US)",
volume = "15",
journal = "Journal of neural engineering",
issn = "1741-2560",
publisher = "IOP Publishing Ltd.",
number = "2",
}