Raman difference studies of protein-nucleic acid interactions

Hua Deng, Robert Callender

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Raman difference spectroscopy combined with isotope editing procedures were employed to obtain the Raman spectra of phosphates, nucleotides, nucleic acids and their fragments when bound to several proteins. The vibrational spectra were analyzed using a variety of empirical and ab initio methods to relate the vibrational wavenumbers to hydrogen bonding strengths, bond orders, bond lengths and geometry and to establish how the proteins bring about these interactions. Some recent results obtained using these methods are reviewed.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalJournal of Raman Spectroscopy
Issue number8
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science
  • Spectroscopy


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