TY - JOUR
T1 - Raman difference studies of protein-nucleic acid interactions
AU - Deng, Hua
AU - Callender, Robert
PY - 1999
Y1 - 1999
N2 - Raman difference spectroscopy combined with isotope editing procedures were employed to obtain the Raman spectra of phosphates, nucleotides, nucleic acids and their fragments when bound to several proteins. The vibrational spectra were analyzed using a variety of empirical and ab initio methods to relate the vibrational wavenumbers to hydrogen bonding strengths, bond orders, bond lengths and geometry and to establish how the proteins bring about these interactions. Some recent results obtained using these methods are reviewed.
AB - Raman difference spectroscopy combined with isotope editing procedures were employed to obtain the Raman spectra of phosphates, nucleotides, nucleic acids and their fragments when bound to several proteins. The vibrational spectra were analyzed using a variety of empirical and ab initio methods to relate the vibrational wavenumbers to hydrogen bonding strengths, bond orders, bond lengths and geometry and to establish how the proteins bring about these interactions. Some recent results obtained using these methods are reviewed.
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U2 - 10.1002/(SICI)1097-4555(199908)30:8<685::AID-JRS405>3.0.CO;2-3
DO - 10.1002/(SICI)1097-4555(199908)30:8<685::AID-JRS405>3.0.CO;2-3
M3 - Article
AN - SCOPUS:19844369236
SN - 0377-0486
VL - 30
SP - 685
EP - 691
JO - Journal of Raman Spectroscopy
JF - Journal of Raman Spectroscopy
IS - 8
ER -