TY - JOUR
T1 - Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms
T2 - A systematic review and meta-analysis
AU - Perry, Kyle A.
AU - Banerjee, Ambar
AU - Melvin, William Scott
PY - 2012/8
Y1 - 2012/8
N2 - Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.
AB - Purpose: Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. Methods: Twenty studies were included. Outcomes analyzed included gastroesophageal reflux disease (GERD) symptom assessment, quality of life, esophageal pH, and esophageal manometry. Results: A total of 1441 patients from 18 studies were included. Radiofrequency treatment improved heartburn scores (P = 0.001), and produced improvements in quality of life as measured by GERD-health-related quality-of-life scale (P = 0.001) and quality of life in reflux and dyspepsia score (P = 0.001). Esophageal acid exposure decreased from a preprocedure Johnson-DeMeester score of 44.4 to 28.5 (P = 0.007). Conclusions: Radiofrequency ablation of the lower esophageal sphincter produces significant improvement in reflux symptoms and may represent an alternative to medical treatment and surgical fundoplication in select patients.
KW - GERD
KW - gastroesophageal reflux disease
KW - radiofrequency
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U2 - 10.1097/SLE.0b013e3182582e92
DO - 10.1097/SLE.0b013e3182582e92
M3 - Review article
C2 - 22874675
AN - SCOPUS:84865515120
SN - 1530-4515
VL - 22
SP - 283
EP - 288
JO - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques
JF - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques
IS - 4
ER -