Abstract
The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.
Original language | English (US) |
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Pages (from-to) | 23-29 |
Number of pages | 7 |
Journal | Journal of Neuro-Oncology |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1986 |
Externally published | Yes |
Keywords
- brain tumors
- polyamines
- positron emission tomography
- putrescine
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research