Putative mechanisms of the relationship between obesity and migraine progression

Marcelo E. Bigal, Richard B. Lipton

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Studies suggest that obesity is associated with migraine progression from an episodic into a chronic form. We discuss putative mechanisms to justify this relationship. Several of the inflammatory mediators that are increased in obese individuals are important in migraine pathophysiology, including interleukins and calcitonin gene-related peptide. Both migraine and obesity are prothrombotic states. Substances that are important in metabolic control are nociceptive at certain levels. Hypothalamic dysfunction in the orexin pathways seems to be a risk factor for both conditions. In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalCurrent pain and headache reports
Issue number3
StatePublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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