TY - JOUR
T1 - Pulmonary Mycobacterium kyorinense disease
T2 - A case report and review of literature
AU - Saranathan, Rajagopalan
AU - Padmapriyadarsini, Chandrasekaran
AU - Sivaramakrishnan, Gomathi
AU - Perumal, Bhavani
AU - Kannayan, Silambuchelvi
AU - Joseph, Bency
AU - Gopalan, Narendran
AU - Hanna, Luke
N1 - Funding Information:
We would like to thank the Doctors, nurses and staff of the Department of Clinical Research, Department of Bacteriology and HIV-laboratory for their tireless contribution to the management of this patient. We extend our acknowledgments to Dr. Lavanya, District TB Officer, Chennai, Medical officers of the Revised National TB Control Programme and Dr. Srikanth Tripathy, Director, NIRT, for extending their support towards the management of NTM patients. This work is supported by an extramural grant from the Indian Council of Medical Research, Government of India.
Publisher Copyright:
© 2019 Indian Society of Anaesthetists. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We report here the first case of pulmonary infection due to Mycobacterium kyorinense in a 55-year-old hypertensive woman treated for pulmonary tuberculosis earlier on two occasions. She presented with productive cough, intermittent episode of left-sided chest pain, loss of appetite, low-grade fever, and breathlessness. Sputum cultures revealed non-tuberculous mycobacteria (NTM). She remained persistently symptomatic with sputum cultures positive for acid-fast bacilli even after 6 months of treatment. Hence, a 16SrRNA gene amplification and sequencing were done that revealed M. kyorinense. Based on the guidelines of the American Thoracic Society, she was started on weight-based dosing of clarithromycin, levofloxacin, ethambutol, isoniazid and injection amikacin daily. The patient improved symptomatically and became culture-negative after 3 months of therapy with the above regimen and continued to be culture negative for 12 months of treatment. She continues to remain symptom-free without evidence of any clinical or bacteriological relapse.
AB - We report here the first case of pulmonary infection due to Mycobacterium kyorinense in a 55-year-old hypertensive woman treated for pulmonary tuberculosis earlier on two occasions. She presented with productive cough, intermittent episode of left-sided chest pain, loss of appetite, low-grade fever, and breathlessness. Sputum cultures revealed non-tuberculous mycobacteria (NTM). She remained persistently symptomatic with sputum cultures positive for acid-fast bacilli even after 6 months of treatment. Hence, a 16SrRNA gene amplification and sequencing were done that revealed M. kyorinense. Based on the guidelines of the American Thoracic Society, she was started on weight-based dosing of clarithromycin, levofloxacin, ethambutol, isoniazid and injection amikacin daily. The patient improved symptomatically and became culture-negative after 3 months of therapy with the above regimen and continued to be culture negative for 12 months of treatment. She continues to remain symptom-free without evidence of any clinical or bacteriological relapse.
KW - 16SrRNA
KW - non-tuberculous mycobacteria
KW - rifampicin resistance
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U2 - 10.4103/ijmm.IJMM_19_94
DO - 10.4103/ijmm.IJMM_19_94
M3 - Article
C2 - 31424025
AN - SCOPUS:85070886536
SN - 0255-0857
VL - 37
SP - 127
EP - 131
JO - Indian Journal of Medical Microbiology
JF - Indian Journal of Medical Microbiology
IS - 1
ER -
