Psychiatric comorbidities of episodic and chronic migraine

Dawn C. Buse, Stephen D. Silberstein, Aubrey N. Manack, Spyros Papapetropoulos, Richard B. Lipton

Research output: Contribution to journalReview articlepeer-review

245 Scopus citations


Migraine is a prevalent disabling neurological disorder associated with a wide range of medical and psychiatric comorbidities. Population- and clinic-based studies suggest that psychiatric comorbidities, particularly mood and anxiety disorders, are more common among persons with chronic migraine than among those with episodic migraine. Additional studies suggest that psychiatric comorbidities may be a risk factor for migraine chronification (i.e., progression from episodic to chronic migraine). It is important to identify and appropriately treat comorbid psychiatric conditions in persons with migraine, as these conditions may contribute to increased migraine-related disability and impact, diminished health-related quality of life, and poor treatment outcomes. Here, we review the current literature on the rates of several psychiatric comorbidities, including depression, anxiety, and post-traumatic stress disorder, among persons with migraine in clinic- and population-based studies. We also review the link between physical, emotional, and substance abuse, psychiatric disorders, and migraine. Finally, we review the data on psychiatric risk factors for migraine chronification and explore theories and evidence underlying the comorbidity between migraine and these psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)1960-1969
Number of pages10
JournalJournal of Neurology
Issue number8
StatePublished - Aug 2013


  • Anxiety
  • Chronification
  • Comorbidity
  • Depression
  • Migraine
  • Psychiatric

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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