Abstract
PSTPIP1 and PSTPIP2 are expressed predominantly in the hematopoietic system where their C-terminal tyrosine phosphorylation is regulated by PEST family phosphatases. Both proteins deform membranes via their conserved F-BAR domains and regulate actin organization, but their actin regulatory activities differ. PSTPIPl negatively regulates actin po lymerization by recruiting PTP-PEST to WASP and mediating dephosphorylation o f WASP at Y291. PSTPIP2 bundles actin and increases filopodia formation. Mutations in human PSTPIPl and mouse PSTPIP2 cause autoinflammatory diseases. Analysis o f the actions o f these proteins promises to reveal novel mechanisms for the regulation o f the inflammatory response involving macrophages and osteoclasts.
| Original language | English (US) |
|---|---|
| Title of host publication | The Pombe Cdc15 Homology Proteins |
| Publisher | CRC Press |
| Pages | 49-61 |
| Number of pages | 13 |
| ISBN (Electronic) | 9781498712798 |
| ISBN (Print) | 9781587063138 |
| DOIs | |
| State | Published - Jan 1 2009 |
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
