Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


PSTPIP1 and PSTPIP2 are expressed predominantly in the hematopoietic system where their C-terminal tyrosine phosphorylation is regulated by PEST family phosphatases. Both proteins deform membranes via their conserved F-BAR domains and regulate actin organization, but their actin regulatory activities differ. PSTPIPl negatively regulates actin po­ lymerization by recruiting PTP-PEST to WASP and mediating dephosphorylation o f WASP at Y291. PSTPIP2 bundles actin and increases filopodia formation. Mutations in human PSTPIPl and mouse PSTPIP2 cause autoinflammatory diseases. Analysis o f the actions o f these proteins promises to reveal novel mechanisms for the regulation o f the inflammatory response involving macrophages and osteoclasts.

Original languageEnglish (US)
Title of host publicationThe Pombe Cdc15 Homology Proteins
PublisherCRC Press
Number of pages13
ISBN (Electronic)9781498712798
ISBN (Print)9781587063138
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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