Pseudohypoparathyroidism: The Molecular Basis for Hormone Resistance — A Retrospective

A. M. Spiegel, M. A. Levine, S. J. Marx, G. D. Aurbach

Research output: Contribution to journalEditorialpeer-review

15 Scopus citations


Fuller Albright coined the term “pseudohypoparathyroidism” to describe hypoparathyroidism caused by target-organ resistance to the action of parathyroid hormone, as opposed to a simple deficiency of the hormone.1 The resistance to parathyroid hormone in pseudohypoparathyroidism Type I is thought to be due to a defect in the hormone receptor-adenylate cyclase complex, since patients with this disorder do not have the brisk rise in urinary cyclic AMP excretion that normally follows administration of parathyroid hormone.2 (Pseudohypoparathyroidism Type II is a much rarer disorder in which the urinary cyclic AMP response is normal but the phosphaturic response is defective.3) These were.

Original languageEnglish (US)
Pages (from-to)679-681
Number of pages3
JournalNew England Journal of Medicine
Issue number11
StatePublished - Sep 9 1982
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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