TY - JOUR
T1 - Pseudocholinesterase deficiency in a octogenarian undergoing total intravenous anesthesia; implications for neuromonitoring
AU - Wecksell, Matthew
AU - Koutsospyros, Demetri
N1 - Publisher Copyright:
© 2015, American University of Beirut. All rights reserved.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Pseudocholinesterase deficiency manifests as prolonged motor blockade after the administration of succinylcholine. A previously unknown homozygous form of the disease, became apparent during a lumbar laminectomy seriously limiting the ability to monitor motor evoked potentials and perform electromyelography (EMG). Moreover, concerns were raised as to how the enzyme deficiency would affect the metabolism of remifentanil and other esters during a total intravenous anesthetic. We present the perioperative management of the patient and a literature review of the syndrome. The patient provided written permission for the authors to publish this report. At our institution, IRB review and approval is not required for a single case report.
AB - Pseudocholinesterase deficiency manifests as prolonged motor blockade after the administration of succinylcholine. A previously unknown homozygous form of the disease, became apparent during a lumbar laminectomy seriously limiting the ability to monitor motor evoked potentials and perform electromyelography (EMG). Moreover, concerns were raised as to how the enzyme deficiency would affect the metabolism of remifentanil and other esters during a total intravenous anesthetic. We present the perioperative management of the patient and a literature review of the syndrome. The patient provided written permission for the authors to publish this report. At our institution, IRB review and approval is not required for a single case report.
UR - http://www.scopus.com/inward/record.url?scp=84939528787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939528787&partnerID=8YFLogxK
M3 - Article
C2 - 26442391
AN - SCOPUS:84939528787
SN - 0544-0440
VL - 23
SP - 157
EP - 162
JO - Middle East Journal of Anesthesiology
JF - Middle East Journal of Anesthesiology
IS - 2
ER -