TY - JOUR
T1 - Pruritus in chronic kidney disease
AU - Uppal, Nupur N.
AU - Corona, Antonio
AU - Fishbane, Steven
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Purpose of reviewAmong the many difficult symptoms that patients with kidney disease experience, pruritus is one of the most frequent and troubling. Because a substantial amount of new information has accumulated, we seek here to review the subject.Recent findingsPruritus is not only a common problematic symptom among patients with kidney disease, but its considerably more frequent than nephrologists recognize. The result for patients is not just uncomfortable itch but degraded quality of life as well. The pathogenesis is increasingly understood, but many aspects remain to be fully resolved. Importantly, research is progressing on treatment, leading to the first approved medication in the United States, difelikefalin, in August, 2021.SummaryAs nephrology is progressing to a greater focus on patient symptoms, recognition of the importance of pruritus has led to increased interest and improved diagnosis and treatment options.
AB - Purpose of reviewAmong the many difficult symptoms that patients with kidney disease experience, pruritus is one of the most frequent and troubling. Because a substantial amount of new information has accumulated, we seek here to review the subject.Recent findingsPruritus is not only a common problematic symptom among patients with kidney disease, but its considerably more frequent than nephrologists recognize. The result for patients is not just uncomfortable itch but degraded quality of life as well. The pathogenesis is increasingly understood, but many aspects remain to be fully resolved. Importantly, research is progressing on treatment, leading to the first approved medication in the United States, difelikefalin, in August, 2021.SummaryAs nephrology is progressing to a greater focus on patient symptoms, recognition of the importance of pruritus has led to increased interest and improved diagnosis and treatment options.
KW - chronic kidney disease
KW - difelikefalin
KW - pruritus
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U2 - 10.1097/MNH.0000000000000824
DO - 10.1097/MNH.0000000000000824
M3 - Review article
C2 - 35851332
AN - SCOPUS:85135129475
SN - 1062-4821
VL - 31
SP - 435
EP - 441
JO - Current opinion in nephrology and hypertension
JF - Current opinion in nephrology and hypertension
IS - 5
ER -