Protein targeting pathways and sorting signals in epithelial cells

Enrique Rodriguez-Boulan, Geri Kreitzer, David Cohen, Vera Bonilha, Anne Müsch

Research output: Chapter in Book/Report/Conference proceedingChapter


A large body of knowledge has been accumulated in the last two decades on the nature of the mechanisms responsible for the polarization of epithelial cells (Rodriguez- Boulan and Nelson, 1989; Rodriguez-Boulan and Powell, 1992). Three fundamental types of mechanisms have emerged that contribute to epithelial polarity (Figure 7.1): (1) intracellular sorting and polarized delivery of proteins and lipids to the cell surface (Figure 7.1, center); (2) “trapping” interactions with domain-restricted cytoskeleton elements (Figure 7.1, right); and (3) diffusive restriction by the tight junctions (Figure 7.1, left). This chapter deals primarily with the first type.

Original languageEnglish (US)
Title of host publicationTight Junctions
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781420038538
ISBN (Print)9780849323836
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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