TY - JOUR
T1 - Protein sorting in the Golgi complex
T2 - Shifting paradigms
AU - Rodriguez-Boulan, Enrique
AU - Müsch, Anne
N1 - Funding Information:
We gratefully acknowledge the support of grants from NIH and from the Research to Prevent Blindness Foundation (ERB) and from the American Heart Association (AM). We also gratefully acknowledge support from the Dyson Foundation.
PY - 2005/7/10
Y1 - 2005/7/10
N2 - The paradigms for transport along the biosynthetic route have changed dramatically over the past 15 years. Unlike the situation 15 years ago, the current paradigm involves sorting signals practically at every step of the pathway. In particular, at the exit from the Golgi complex, apical, basolateral and lysosomal targeting signals result in the generation of a variety of routes. Furthermore, it is now quite clear that not all sorting in the biosynthetic route occurs in the Golgi complex or the Trans Golgi Network (TGN). Sorting may occur distally to the Golgi, in recycling endosomes or in budded tubulosaccular structures, or it may occur proximally to the Golgi complex, at the exit from the ER. Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions.
AB - The paradigms for transport along the biosynthetic route have changed dramatically over the past 15 years. Unlike the situation 15 years ago, the current paradigm involves sorting signals practically at every step of the pathway. In particular, at the exit from the Golgi complex, apical, basolateral and lysosomal targeting signals result in the generation of a variety of routes. Furthermore, it is now quite clear that not all sorting in the biosynthetic route occurs in the Golgi complex or the Trans Golgi Network (TGN). Sorting may occur distally to the Golgi, in recycling endosomes or in budded tubulosaccular structures, or it may occur proximally to the Golgi complex, at the exit from the ER. Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions.
KW - Default pathway
KW - Golgi complex
KW - Polarized secretion
KW - Protein trafficking
KW - Sorting signal
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U2 - 10.1016/j.bbamcr.2005.04.007
DO - 10.1016/j.bbamcr.2005.04.007
M3 - Review article
C2 - 15927284
AN - SCOPUS:20544431747
SN - 0167-4889
VL - 1744
SP - 455
EP - 464
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 3 SPEC. ISS.
ER -