Protein degradation, aggregation, and misfolding

Ana Maria Cuervo, Esther S.P. Wong, Marta Martinez-Vicente

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)S49-S54
JournalMovement Disorders
Issue numberSUPPL. 1
StatePublished - 2010


  • Autophagy
  • Lysosomes
  • Neurodegeneration
  • Proteases
  • Protein aggregates

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Protein degradation, aggregation, and misfolding'. Together they form a unique fingerprint.

Cite this