TY - JOUR
T1 - Prostate immunology
T2 - A challenging puzzle
AU - Silva, Juliete Aparecida F.
AU - Calmasini, Fabiano
AU - Siqueira-Berti, Aline
AU - Moraes-Vieira, Pedro M.M.
AU - Quintar, Amado
AU - Carvalho, Hernandes F.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/11
Y1 - 2020/11
N2 - Mucosal immunity defines the relationship of surfaces in contact with the environment and integrates diverse tissues such as epidermis, gum, nose, gut, uterus and prostate with the immune system. Although considered part of a system, each mucosa presents specific immune features beyond the barrier and secretory functions. Information regarding the mucosal immunology of the male reproductive tract and the prostate gland in particular is scarce. In this review, we approach the prostate as an epithelial barrier and as part of the mucosal immune system. Finally, we also raise a series of questions that will improve the understanding of this gland, its role in reproduction and its sensitivity/resistance to disease.
AB - Mucosal immunity defines the relationship of surfaces in contact with the environment and integrates diverse tissues such as epidermis, gum, nose, gut, uterus and prostate with the immune system. Although considered part of a system, each mucosa presents specific immune features beyond the barrier and secretory functions. Information regarding the mucosal immunology of the male reproductive tract and the prostate gland in particular is scarce. In this review, we approach the prostate as an epithelial barrier and as part of the mucosal immune system. Finally, we also raise a series of questions that will improve the understanding of this gland, its role in reproduction and its sensitivity/resistance to disease.
KW - Benign prostate hyperplasia
KW - IgA secretion
KW - Mucosal immunity
KW - Prostate
KW - Prostatitis
UR - http://www.scopus.com/inward/record.url?scp=85089749295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089749295&partnerID=8YFLogxK
U2 - 10.1016/j.jri.2020.103190
DO - 10.1016/j.jri.2020.103190
M3 - Review article
C2 - 32853844
AN - SCOPUS:85089749295
SN - 0165-0378
VL - 142
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
M1 - 103190
ER -