Abstract
The network of protein–protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease, providing unique tools for dissecting these functions. The BCL-2 family of proteins is a prime example of targeting protein–protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in cancer, autoimmune and aging-associated diseases.
Original language | English (US) |
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Pages (from-to) | 133-142 |
Number of pages | 10 |
Journal | Current Opinion in Chemical Biology |
Volume | 39 |
DOIs | |
State | Published - Aug 2017 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry